Poloxamers | Uses, Suppliers, and Specifications
Poloxamers are a family of closely related block copolymers of poly(ethylene oxide) and poly(propylene oxide) that exhibit amphiphilic properties and corresponding to the chemical formula, HO(C2H4O)a(C3H6O)b(C2H4O)aH. Grades included in pharmacopoeia include Poloxamer 124; Poloxamer 188; Poloxamer 237; Poloxamer 338, and Poloxamer 407. They occur as white, waxy, free-flossing prilled granules or as solids. They are practically odourless and tasteless.
Pharmacopoeial Compliance: USP-NF; Ph.Eur; B.P; I.P
Synonyms and Trade Names: Poloxamer; Polyethylene- propylene glycol copolymer; Polyoxvethylene-Polyoxypropylene Copolymer; Lutrol®; Pluronic®; Synperonic™; Antarox®
Uses and Applications: Non-Ionic Surfactants; Dispersing Agent; Solubilising Agent; Tablet Lubricant; Wetting Agent; and Dissolution Rate Enhancer
Chemical Structure & Identifiers
Applications in Pharmaceutical Formulations or Technology
Safety and Precautions
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References and Literature Used
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