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Search for COVID-19 drugs boosted by SARS discovery

An extensive search and testing of current drugs and drug-like compounds has revealed compounds previously developed to fight SARS might also work against COVID-19. Using the National Drug Discovery Centre, researchers from the Walter and Eliza Hall Institute identified drug-like compounds that could block a key coronavirus protein called PLpro. This protein, found in all coronaviruses, is essential for the virus to hijack and multiply within human cells, and disable their anti-viral defences.

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73,000 Scientists collaborate over new COVID-19 Data Portal to speed up vaccine development

More than 73,000 users collaborate on new online platform set up by the European Open Science Cloud Initiative, where scientists share COVID-19 data and accelerate our understanding of the virus to help develop treatments and vaccines quicker. A new website that allows scientists to share difficult-to-find SARS-CoV-2 data from clinical trials, research centres, hospitals and national healthcare systems, has seen thousands of users collaborating to help beat the novel coronavirus.

Phase I clinical trial initiated for monoclonal antibody combination for the prevention and treatment of COVID-19

The first participants have been dosed in a Phase I trial of AZD7442, a combination of two monoclonal antibodies (mAbs) in development for the prevention and treatment of COVID-19. The trial, called NCT04507256, will evaluate the safety, tolerability and pharmacokinetics of AZD7442.(1) The trial will include up to 48 healthy participants in the UK aged 18 to 55 years and is funded by the

Recro Gainesville Expands Mfg. Capabilities

Recro Gainesville has expanded its capabilities by adding a new tablet manufacturing suite and growing its development team. An FDA- and DEA-approved provider of solid oral dose manufacturing services for the pharmaceutical industry, Recro specializes in extended release and controlled substances.

BASF Gains EXCiPACT Certification

BASF has received EXCiPACT Certification for pharmaceutical excipients for a group of its polyvinylpyrrolidone (Kollidon) polymers produced in Ludwigshafen. The certificate was issued by mdc medical device certification GmbH, one of EXCiPACT’s certification bodies.

ROQUETTE Expands Excipient/API Services

ROQUETTE has opened a new pharmaceutical Application Development Center at its site at Lestrem, France, expanding its services for excipients and active ingredients to the pharmaceutical industry.

The 800 m2 lab offers compression, film coating or granulation, as well as the development of new galenic forms, one of the company’s latest innovations. ROQUETTE has developed an excipient for orodispersible tablets, a new form that melts directly in the mouth without the need for water, providing immediate action for the patient. The company will also provide expertise for pharmaceutical formulation.

Determining Solvent Evaporation Rates Faster with Science-based Tool

These properties have to be balanced against other factors such as toxicity, green credentials, odor and the all-important solubility behavior encoded in Hansen Solubility Parameters, HSP.

Here we look at ways in which things become complicated – and what we can do about it. Surprisingly, HSP turn out to be a helpful pragmatic tool for dealing with the complications.

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